Mn(II), Ni(II), and Cu(II) Complexes of Artmisinin Derivatives: Synthesis, Characterization and Antimicrobial Activities
نویسندگان
چکیده
A range of transition metals ligated by sesquiterpene lactone-artesunate (ATS) have been investigated. Syntheses of Cu(II), Ni(II), and Mn(II) complexes of decahydro-3,6,9-trimethyl3,12-epoxy-12H-pyrano[4,3-j]1,2-benzodioxepin10-ol hydrogen succinate were prepared by a direct aqueous substitution reaction in methanol. Structural elucidations of the complexes were determined using X-Ray Diffractrometry along with elemental analysis and FT-IR. The IR absorption revealed that ATS acts as monodentate specie through carbonyl group on coordination. It also acts as bidentate specie upon deprotonation of the carboxylic group. The [Cu(ATS)ac.H2O] was further characterized with X-ray powder diffraction studies which showed that it has a tetrahedral geometry. Corresponding complexes and their ligands were screened against bacteria and fungi: Staphylococcus aureus, Pseudomonas aeruginosa, Proteus hauseri ATCC 13315, E. coli ATCC35218, Rhizopus stolonifer, and Aspergillus niger, respectively, to investigate their antimicrobial activities. [Mn(ATS)2Cl2] showed the highest inhibitory level over Ni(II) and Cu(II) complex and the parent ligand drug(ATS). (
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